基本素養 Basic Literacy
課程概述 Course Description以書報討論方式訓練邏輯思考，科學批判能力，以及演講技巧
課程學習目標 Course Objectives
課程進度 Progress Description
|進度說明 Progress Description|
|1||Introduction; Adipocyte extracellular vesicles carry enzymes and fatty acids that stimulate mitochondrial metabolism and remodeling in tumor cells. Embo J 39, e102525 (2020).; Mitochondrial complex III is necessary for endothelial cell proliferation during angiogenesis. Nat Metab 1, 158-171 (2019).|
|2||lncRNA epigenetic landscape analysis identifies EPIC1 as an oncogenic lncRNA that interacts with MYC and promotes cell-cycle progression in cancer. Cancer Cell 33, 706-720 (2018).; Gastric microbial community profiling reveals a dysbiotic cancer-associated microbiota. Gut 67, 226-236 (2018).|
|3||Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder, and intelligence. Mol Psychiatry 25, 844-853 (2020).; METTL3 is essential for postnatal development of brown adipose tissue and energy expenditure in mice. Nat Commun 11, 1648 (2020).|
|4||Tinagl1 suppresses triple-negative breast cancer progression and metastasis by simultaneously inhibiting integrin/FAK and EGFR signaling. Cancer Cell 35, 64-80 (2019).; Dermal sheath contraction powers stem cell niche relocation during hair cycle regression. Science 367, 161-166 (2020).|
|5||Mid-autumn festival holiday|
|6||National Day observed|
|7||Endothelial Sox17 promotes allergic airway inflammation. J Allergy Clin Immunol 144, 561-573 (2019).; Defective synaptic connectivity and axonal neuropathology in a human iPSC-based model of familial Parkinson's disease. Proc Natl Acad Sci U S A 114, e3679-e3688 (2017).|
|8||Oncogenic KRAS-driven metabolic reprogramming in pancreatic cancer cells utilizes cytokines from the tumor microenvironment. Cancer Discov 10, 608-625 (2020).; Activation of JUN in fibroblasts promotes pro-fibrotic programme and modulates protective immunity. Nat Commun 11, 2795 (2020).|
|9||IL (Interleukin)-10-STAT3-galectin-3 axis is essential for osteopontin-producing reparative macrophage polarization after myocardial infarction. Circulation 138, 2021-2035 (2018).; Human-induced pluripotent stem cell model of trastuzumab-induced cardiac dysfunction in patients with breast cancer. Circulation 139, 2451-2465 (2019).|
|10||Diurnal rhythms in gene expression in the prefrontal cortex in schizophrenia. Nat Commun 10, 1-11 (2019).; Dysregulation of mitochondrial Ca2+ uptake and sarcolemma repair underlie muscle weakness and wasting in patients and mice lacking MICU1. Cell Rep 29, 1274-1286 (2019).|
|11||Cardiac TRPV1 afferent signaling promotes arrhythmogenic ventricular remodeling after myocardial infarction. JCI Insight 5, e124477 (2020).; Innate lymphoid cells support regulatory T cells in the intestine through interleukin-2. Nature 568, 405-409 (2019).|
|12||ALK phosphorylates SMAD4 on tyrosine to disable TGF-β tumour suppressor functions. Nat Cell Biol 21, 179-189 (2019).; Human pluripotency is initiated and preserved by a unique subset of founder cells. Cell 177, 910-924 (2019).|
|13||CKAP4, a DKK1 receptor, is a biomarker in exosomes derived from pancreatic cancer and a molecular target for therapy. Clin Cancer Res 25, 1936-1947 (2019).; Priming mobilization of hair follicle stem cells triggers permanent loss of regeneration after alkylating chemotherapy. Nat Commun 10, 3694 (2019).|
|14||Interleukin-36 cytokines alter the intestinal microbiome and can protect against obesity and metabolic dysfunction. Nat Commun 10, 4003 (2019).; Nanoscale metal-organic framework mediates radical therapy to enhance cancer immunotherapy. Chem 5, 1892-1913 (2019).|
|15||TDP-43 dysfunction restricts dendritic complexity by inhibiting CREB activation and altering gene expression. Proc Natl Acad Sci U S A 117, 11760-11769 (2020).; REEP5 depletion causes sarco-endoplasmic reticulum vacuolization and cardiac functional defects. Nat Commun 11, 965 (2020).|
|16||Reversing a model of Parkinson's disease with in situ converted nigral neurons. Nature 582, 550-556 (2020).; The Mir181ab1 cluster promotes KRAS-driven oncogenesis and progression in lung and pancreas. J Clin Invest 130, 1879-1895 (2020).|
|17||New Year Day|
|18||Enhancing the regenerative effectiveness of growth factors by local inhibition of interleukin-1 receptor signaling. Sci Adv 6, e7602 (2020).;|
有關課程其他調查 Other Surveys of Courses1.本課程是否規劃業界教師參與教學或演講?
Is there any industry specialist invited in this course? How many times?
Are there any internships involved in the course? How many hours?
Is this course recognized as an academic ethics course? In the course how many hours are regarding academic ethics topics?
Is this course recognized as a Community engagement and Service learning course? Which community will be engaged?