基本素養 Basic Literacy

人文素養
Spirit of Humanism
公民素養
Civic Concern
社會關懷
Social Concern
國際視野
Global Vision

核心能力 Competence

專業與跨域能力
Professional and Interdisciplinary Abilities
思考與判斷能力
Critical Thinking Abilities
良好的溝通能力
Language Proficiency and Communication Abilities
創新與領導能力
Innovative and Leadership Abilities

課程概述 Course Description

本課程主要教授學生了解基因體編輯技術之使用原理以及如何運用於疾病研究。藉此培養學生應用此一新穎科學於研究之能力
The course is aimed to teach students to the principle and the application of genome editing technologies for studying disease.

課程學習目標 Course Objectives

  • 透過不同領域之文獻探討用以了解基因體編輯技術於實際案例中之執行與運用
  • 藉由討論了解如何設計實驗以及分析實際結果
  • 學生藉由口頭報告之方式同時提升學生理解力以及口說之能力
  • 課程進度 Progress Description

    進度說明 Progress Description
    1Course Introduction
    2Biology and Clinical Implications of the 19q13 Aggressive Prostate Cancer Susceptibility Locus
    3CRISPR-Mediated Gene Editing to Assess the Roles of Tet2 and Dnmt3a in Clonal Hematopoiesis and Cardiovascular Disease
    4Disruption of C1galt1 Gene Promotes Development and Metastasis of Pancreatic Adenocarcinomas in Mice
    5Review
    6Efficient CRISPRCas9-mediated editing of trinucleotide repeat expansion in myotonic dystrophy patient-derived iPS and myogenic cells
    7Efficient RNA drug delivery using red blood cell extracellular vesicles
    8GFAP Mutations in Astrocytes Impair Oligodendrocyte Progenitor Proliferation and Myelination in an hiPSC Model of Alexander Disease
    9Review
    10Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescence
    11Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 with improved proof-reading enhances homology-directed repair.
    12RNA targeting with CRISPR–Cas13
    13Reivew
    14Preclinical modeling highlights the therapeutic potential of hematopoietic stem cell gene editing for correction of SCID-X1
    15RNA-guided transcriptional silencing in vivo with S. aureus CRISPR-Cas9 repressors
    16p53 inhibits CRISPR-Cas9 engineering in human pluripotent stem cells
    17Review
    18Final exam
     以上每週進度教師可依上課情況做適度調整。The schedule may be subject to change.

    有關課程其他調查 Other Surveys of Courses

    1.本課程是否規劃業界教師參與教學或演講? 否
    Is there any industry specialist invited in this course? How many times? No
    2.本課程是否規劃含校外實習(並非參訪)? 否
    Are there any internships involved in the course? How many hours? No
    3.本課程是否可歸認為學術倫理課程? 否
    Is this course recognized as an academic ethics course? In the course how many hours are regarding academic ethics topics? No
    4.本課程是否屬進入社區實踐課程?
    Is this course recognized as a Community engagement and Service learning course? Which community will be engaged?