基本素養 Basic Literacy

核心能力 Competence

培養生物化學與分子生物學的專業知識
Biochemistry and molecular biology professional knowledge.
學習其他生物醫學與生物技術相關領域知識
Learn knowledge in other biology medicine and biology techniques fields.
培養閱讀與整理新知及表達研究成果的能力
Reading and collection new knowledge and presentation research results.
培養生物醫學各領域的知識技能與實驗設計能力與技能
Biology medicine knowledge in every field and experiment design and techniques.
加強獨立從事研究能力
Enhance independent research ability.

課程概述 Course Description

蛋白質轉譯是維持細胞功能很重要的步驟,如果蛋白質轉譯功能失調,將會引起很多疾病。本課程希望透過1)介紹基本的蛋白質轉譯步驟; 2)介紹蛋白質轉譯如何影響基因表達及3)介紹蛋白質轉譯失調與疾病的關聯。期望透過此課程讓研究生對於蛋白質轉譯領域研究有一定程度了解,並引發研究生學習動機,及引導解決問題的能力。此課程於每一個段落會有英文期刊報告及討論。
Protein translation is one of the most critical cellular processes in the cell. The misregulation of translation will often lead to disease, including cancer, infectious diseases, neurological diseases, metabolic diseases, immunological diseases, etc. Better understanding of this relevant biological process will provide opportunities to treat these diseases. This lecture will start from introducing the basics of how translation machinery works following by introducing how protein translation regulates gene expression. The lecture will be ended by showing examples regarding misregulation of translation in diseases. Besides lectures, intensive discussions of experimental design and future directions will a major part of this course.

課程學習目標 Course Objectives

  • The basics of protein translation
  • The signals on the mRNA that affect protein synthesis
  • The trans factors that affect protein synthesis
  • Misregulation of protein translation in diseases
  • 課程進度 Progress Description

    進度說明 Progress Description
    1Introduction
    2Translation of messenger RNA
    3No lecture due to Moon Festival vacation
    4Principles of translational control
    5translation initiation, elongation, termination, and recycling
    6Selected paper discussion
    7Cis elements in translation regulation: riboswitch
    8Cis elements in translation regulation: Internal Ribosome Entry sites (IRESs)
    9Cis elements in translation regulation: Recoding
    10Selected paper discussion
    11Trans elements in translation regulation: mRNA localization
    12Trans elements in translation regulation: RNA binding proteins
    13Trans elements in translation regulation: the short and long story
    14Selected paper discussion
    15Translation regulation of RNA viruses
    16Translation regulation in neurodegenerative diseases
    17Selected paper discussion
     以上每週進度教師可依上課情況做適度調整。The schedule may be subject to change.

    課程是否與永續發展目標相關調查
    Survey of the conntent relevant to SDGs

    本課程與SDGs相關項目如下:
    This course is relevant to these items of SDGs as following:
    • 健康與福祉 (Good health and Well Being)
    • 就業與經濟成長 (Decent work and Economic growth)
    • 工業、創新與基礎建設 (Industry Innovation and infrastructure)

    有關課程其他調查 Other Surveys of Courses

    1.本課程是否規劃業界教師參與教學或演講? 否
    Is there any industry specialist invited in this course? How many times? No
    2.本課程是否規劃含校外實習(並非參訪)? 否
    Are there any internships involved in the course? How many hours? No
    3.本課程是否可歸認為學術倫理課程? 否
    Is this course recognized as an academic ethics course? In the course how many hours are regarding academic ethics topics? No
    4.本課程是否屬進入社區實踐課程?
    Is this course recognized as a Community engagement and Service learning course? Which community will be engaged?